GREENE COUNTY, TN  —  A multi-vehicle crash has closed a portion of southbound Interstate 81 in Greene County and left crews cleaning up the spilled cargo from a tractor-trailer.

According to the Tennessee Department of Transportation SmartWay Traffic Map, the crash happened after 2 a.m. near mile marker 42.

The southbound right lane and shoulder remain closed as of 9 a.m.

According to a tweet from TDOT spokesperson Mark Nagi, the crash involved a commercial vehicle. Crews were still cleaning up the spilled cargo as of 8:12 a.m.

A preliminary crash report from the Tennessee Highway Patrol states the crash occurred when a tractor-trailer changed lanes and hit a Chevrolet Spectrum. Both of the vehicles left the roadway, the report states.

Both drivers were injured in the crash, according to THP. The extent of the injuries was not clear.

Charges are pending against the driver of the tractor-trailer following an investigation. THP identified the driver as Kemel Diaz Garcia, 45, of Keene, Texas.

TDOT has not provided a time that the crash is expected to be cleared.