Roan Mountain and Hampton Volunteer Fire Departments were called to a fully involved house fire in the 7000 block of Highway 19E on Thursday morning.
Firefighters said passing drivers had discovered the burning home just after 5 a.m. and tried to knock on the door but got no answer.
The home did have power at the time of the fire but was not occupied.
Fire crews said the home sustained heavy smoke and fire damage.
The cause of the fire remains unknown.